Seasons 1 and 8
Sam and Dean
Dean looks like he’s had every past ounce of joy and hope sucked out of him.
A lot of the softness and kindness in Sam’s face is gone, and he looks hurt by the world and angry with it.
Sam is the change from “it’s in the past” to “this is my life”
Dean is the change from “what I do matters” to “it doesn’t matter what I do”